A compound of Formula (III): ** Formula ** and / or its pharmaceutically acceptable salt, wherein: J is N； J 'is CR1 where R1 is hydrogen； Ar is phenyl, optionally substituted with one, two, three or four substituents independently selected from alkyl, hydroxy, alkoxy, halo, haloalkyl, haloalkoxy and cyano； R2 is hydrogen, alkyl, alkynyl, acyl, alkoxycarbonyl, haloalkyl, cycloalkyl optionally substituted with amino, alkylamino, dialkylamino or hydroxy, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkoxyalkyloxyalkyl, aminoalkyl, heterocyclyl (wherein heterocyclyl is optionally substituted or two Substituents independently selected from alkyl, halo, hydroxy, alkoxy, hydroxyalkyl, alkoxyalkyl, alkoxyalkyloxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted heterocyclyl, heterocyclylalkyl (wherein the heterocyclyl-alkyl heterocyclyl ring is optionally substituted two or three substituents independently selected from alkyl, halo, acyl, hydroxy, alkoxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted heterocyclyl), aralkyl, heteroaralkyl, phenyl or heteroaryl (wherein the phenyl ring in aralkyl, the heteroaryl ring in heteroaralkyl, phenyl and heteroaryl are optionally substituted with one, two or three substituents wherein two of the optional substituents are independently selected from alkyl, hydroxy, alkoxy, halo, haloalkyl, haloalkoxy and cyano, and one of the optional substituents is alkyl, cycloalkyl, hydroxy, alkoxy, halo, haloalkyl, haloalkoxy, cyano, hydroxyalkyl, alkoxyalkyl, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl or heterocyclyl )； and Q is alkylene or substituted alkylene； and X is a group of formula (a): ** Formula ** wherein: R3 is hydrogen, alkyl, haloalkyl, hydroxy, alkoxy or halo； and R4 is hydrogen, alkyl, hydroxy, alkoxy or halo； Y is -CO- or -SO2-； Rc is hydrogen, alky
