GAILLARD, PASCALE,QUATTROPANI, ANNA,POMEL, VINCENT,RUECKLE, THOMAS,KLICIC, JASNA,CHURCH, DENNIS
申请号：
ES06793019
公开号：
ES2456000T3
申请日:
2006.08.25
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A pyrazine derivative according to formula (I) ** Formula ** where: A, B, D and E are C, or A is N； B, D and E are C, or A, B and E are C； D is N, so that the ring R is an aromatic ring； R1 is selected from H； halogen, nitro, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl and optionally substituted C2-C6 alkynyl； R2 10 is selected from H, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl and optionally substituted C2-C6 alkynyl； R3 is selected from H, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted alkoxy, optionally substituted aryl and optionally substituted heteroaryl； R4 is selected from optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally heterocycloalkyl substituted, optionally substituted aryl C1-C6 alkyl, optionally substituted C1-C6 alkyl alkoxycarbonyl phenyl, optionally substituted heteroaryl C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C1-C6 alkyl heterocycloalkyl, C2- aryl alkenyl Optionally substituted C6 and optionally substituted C2-C6 heteroaryl alkenyl； n is an integer selected from 0, 1, 2, 3 and 4； where "optionally substituted" refers to groups optionally substituted with 1 to 5 substituents selected from the group consisting of "C1-C6 alkyl", "C2-C6 alkenyl" "C2-C6 alkynyl", "cycloalkyl", "heterocycloalkyl", "C 1 -C 6 aryl aryl", "C 1 -C 6 alkyl heteroaryl", "C 1 -C 6 alkyl cycloalkyl", "C 1 -C 6 alkyl heterocycloalkyl", "amino", "ammonium", "acyl", "acyloxy", "acylamino" "," aminocarbonyl "," alkoxycarbonyl "," ureido "," aryl "," carbamate "," heteroaryl "," sulfinyl "," sulfonyl "," alkoxy "," sulfanyl "," halogen "," carboxy ", trihalomethyl, cyano, hydroxy, m
