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NOVEL BICYCLIC COMPOUND OR SALT THEREOF
专利权人:
发明人:
申请号:
EP12732119.8
公开号:
EP2662357A1
申请日:
2012.01.06
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Provided is a novel bicyclic compound which has an HSP90 inhibitory effect and a carcinostatic effect. Also provided is a pharmaceutical agent which is based on the HSP90 inhibitory effect and is useful in the prevention and/or treatment of a disease involving HSP90, particularly, cancer. The present invention provides a compound represented by the following general formula (I) or a salt thereof wherein at least one of X1, X2, X3, and X4 represents N or N-oxide and the rest thereof are the same or different and each represent C-R2any one or two of Y1, Y2, Y3, and Y4 represent C-R4 and the rest thereof are the same or different and each represent CH or NR1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and OR2 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.R3 represents a hydrogen atom, -CO-R5 etc.R4 represents a hydrogen atom, -CO-R6, -N(R7)(R8) etc.R5 represents a hydroxyl group, an amino group etc.R6 represents a hydroxyl group etc.R7 and R8 are the same or different and each represent a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc. and R9 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.
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