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新型二環式化合物或其鹽
专利权人:
Taiho Pharmaceutical Co. Ltd.;大鵬藥品工業株式會社
发明人:
Makoto KITADE,Satoshi YAMASHITA,Shuichi OHKUBO,北出誠,山下智史,大久保秀
申请号:
HK13112605.7
公开号:
HK1185079B
申请日:
2013.11.11
申请国别(地区):
HK
年份:
2017
代理人:
摘要:
Provided is a novel bicyclic compound which has an HSP90 inhibitory effect and a carcinostatic effect. Also provided is a pharmaceutical agent which is based on the HSP90 inhibitory effect and is useful in the prevention and/or treatment of a disease involving HSP90, particularly, cancer. The present invention provides a compound represented by the following general formula (I) or a salt thereof wherein at least one of X 1 , X 2 , X 3 , and X 4 represents N or N-oxide and the rest thereof are the same or different and each represent C-R 2 ; any one or two of Y 1 , Y 2 , Y 3 , and Y 4 represent C-R 4 and the rest thereof are the same or different and each represent CH or N; R 1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O; R 2 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; R 3 represents a hydrogen atom, -CO-R 5 etc.; R 4 represents a hydrogen atom, -CO-R 6 , -N(R 7 )(R 8 ) etc.; R 5 represents a hydroxyl group, an amino group etc.; R 6 represents a hydroxyl group etc.; R 7 and R 8 are the same or different and each represent a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; and R 9 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.
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