Pyrroloindoles of formula (I) are provided wherein Het is an aromatic or partially unsaturated, monocyclic or bicyclic heterocycle containing between 1 and 4 heteroatoms N, O or S, optionally substituted by R1 or R&prime；1 which are the same or different； R is X-(A-B)n-CONH2, X-(A-B)n-O&mdash；CONH2, X-(A-B)n-NH&mdash；CONH2, X&mdash；(CH2)m-heterocycloalkyl, X(CH2)m-aryl and X&mdash；(CH2)m-heteroaryl wherein X is &mdash；O&mdash；C(O), &mdash；NH&mdash；C(O), NH&mdash；CS, &mdash；NH&mdash；CO&mdash；CH2-O&mdash；； &mdash；NH&mdash；COCH2-S&mdash；CH2-CO&mdash；NH&mdash；； &mdash；NH&mdash；CO&mdash；(CH2)2-SO2-； and &mdash；NH&mdash；CO&mdash；CH2-N(CH3)-CO&mdash；； A and B are the same or different and are each independently a single bond, CH2, CH-alkyl, and CH-aralkyl； n=1, 2 and m=0, 1； R1 and/or R&prime；1 are H, halogen, CF3, nitro, cyano, alkyle, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, and carboxy, free or esterified by an alkyl, carboxamide, CONH(alkyl), CON(alkyl)2, NH&mdash；CO-alkyl, sulfonamide, NH&mdash；SO2-alkyl, S(O)2-NHalkyl, and S(O2)-N(alkyl)2 group, all of said alkyl, alcoxy and alkylthio groups being optionally substituted themselves, said products being in all isomer forms and salts, as medicaments.
