A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as ApoAI or fragment thereof, a lipid and a detergent at a level which is about 5 to 50% of that which would normally cause liver toxicity upon adminstration to a human. The lipid is optimally phosphatidyl choline at about 30 to 50 g/L and the molar ratio of apolipoprotein lipid is optimally in the range 1: 40 to 1: 75. The formulation is useful for treating diseases or conditions such as cardiovascular disease, hypercholesterolaemia and hypocholesterolaemia inclusive of acute coronary syndrome (ACS), atherosclerosis and myocardial infarction.一種包含一載脂蛋白例如Apo-AI或其片段、一脂質以及投與人類時通常會導致肝毒性之約5~50%濃度去污劑之相對低毒性的重組高密度脂蛋白配製物。該脂質係於約30~50g/L的適量磷脂醯膽鹼以及載脂蛋白:脂質的克分子比為在1:40至1:75的適量範圍內。該配製物可有效用於治療疾病或病症例如心血管疾病、高膽固醇血症或低膽固醇血症包括急性冠心病(ACS)、動脈粥樣硬化症和心肌梗塞。
