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Visszaoldott nagysûrûségû lipoprotein kiszerelés és elõállítási eljárása
专利权人:
CSL Limited
发明人:
WRIGHT, Samuel,IMBODEN, Martin,BOLLI, Reinhard Franz,WAELCHLI, Marcel
申请号:
HUE16203579
公开号:
HUE042391T2
申请日:
2011.06.30
申请国别(地区):
HU
年份:
2019
代理人:
摘要:
A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as ApoAl or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50g/L and the molar ratio of apolipoprotein:lipid is optimally in the range 1:40 to 1:75. The formulation is useful for treating diseases or conditions such as cardiovascular disease, hypercholesterolaemia and hypocholesterolaemia inclusive of acute coronary syndrome (ACS), atherosclerosis and myocardial infarction.
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