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NEW ANTIBODY DRUG CONJUGATES (ADCS) AND THE USE THEREOF
专利权人:
发明人:
Hans-Georg Lerchen,Stefanie Hammer,Axel Harrenga,Charlotte Christine Kopitz,Carl Friedrich Nising,Anette Sommer,Beatrix Stelte-Luowig,Christoph Mahlert,Joachim Schuhmacher,Sven Golfier,Simone Greven,S
申请号:
US14364203
公开号:
US20150023989A1
申请日:
2012.12.12
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present application relates to new antibody drug conjugates (ADCs) of N,N dialkylauristatins directed against the target FGFR2, drug metabolites of said ADCs, a method for producing said ADCs, the use of said ADCs for the treatment and/or prevention of illnesses as well as the use of said ADCs for producing pharmaceuticals for the treatment and/or prevention of illnesses, particularly of hyperproliferative and/or angiogenic diseases such as carcinosis. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
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