Lerchen, Hans-Georg,Hammer, Stefanie,Harrenga, Axel,Kopitz, Charlotte Christine,Nising, Carl Friedrich,Sommer, Anette,Stelte-Ludwig, Beatrix,Mahlert, Christoph,Schuhmacher, Joachim,Golfier, Sven,Greve
申请号：
AU2012351685
公开号：
AU2012351685A1
申请日:
2012.12.12
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present application relates to new antibody drug conjugates (ADCs) of N,N dialkylauristatins directed against the target FGFR2, drug metabolites of said ADCs, a method for producing said ADCs, the use of said ADCs for the treatment and/or prevention of illnesses as well as the use of said ADCs for producing pharmaceuticals for the treatment and/or prevention of illnesses, particularly of hyperproliferative and/or angiogenic diseases such as carcinosis. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
