LERCHEN, HANS-GEORG,HAMMER, STEFANIE,HARRENGA, AXEL,KOPITZ, CHARLOTTE CHRISTINE,NISING, CARL FRIEDRICH,SOMMER, ANETTE,STELTE-LUDWIG, BEATRIX,MAHLERT, CHRISTOPH,SCHUHMACHER, JOACHIM,GOLFIER, SVEN,GREVE
申请号：
CA2859255
公开号：
CA2859255A1
申请日:
2012.12.12
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present application relates to new antibody drug conjugates (ADCs) of N,N dialkylauristatins directed against the target FGFR2, drug metabolites of said ADCs, a method for producing said ADCs, the use of said ADCs for the treatment and/or prevention of illnesses as well as the use of said ADCs for producing pharmaceuticals for the treatment and/or prevention of illnesses, particularly of hyperproliferative and/or angiogenic diseases such as carcinosis. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
