Servet Buyuktimkin,Nadir Buyuktimkin,Jagat Singh,John M. Newsam,Dominic King-Smith,Edward T. Kisak
申请号：
US14738554
公开号：
US20150342871A1
申请日:
2015.06.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomycosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent a lower alcohol and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.
