Servet Buyuktimkin,Nadir Buyuktimkin,Jagat Singh,John M. Newsam,Dominic King-Smith,Edward Kisak
申请号：
US13525108
公开号：
US20120309843A1
申请日:
2012.06.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomychosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent a lower alcohol and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.
