Provided herein are the 3'3' cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.本文中提供通式J之3'3'環狀膦酸酯二核苷酸、其醫藥學上可接受之鹽、含有其之醫藥組合物及該等物質與其他藥劑或藥品之組合。本發明亦係關於該等化合物之用途，其係用於治療或預防可藉由STING蛋白質調節來改善之疾病或病狀，諸如癌症或病毒性、過敏性及發炎性疾病。此外，此等物質可用作疫苗中之佐劑。
