Provided herein are 2'2' cyclic phosphonate dinucleotides of formula (J), their pharmaceutically acceptable salts, hydrates or solvates, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, the dinucleotides can be used as adjuvants in vaccines.本文中提供式(J)之2'2'環狀膦酸酯二核苷酸、其醫藥學上可接受之鹽、水合物或溶劑合物，含有其之醫藥組合物以及該等物質與其他藥劑或藥品之組合。本發明亦係關於該等化合物之用途，其係用於治療或預防可藉由STING蛋白質調節來改善之疾病或病狀，諸如癌症或病毒性、過敏性及發炎性疾病。此外，二核苷酸可用作疫苗中之佐劑。
