The present invention provides a medicament comprising a compound having an antagonistic activity against the EP4 receptor as an active ingredient in the prevention and/or treatment of diseases caused by the activation of the EP4 receptor.The compounds represented by the general formula (I) (Wherein all symbols have the same meanings as those described in the description), or a pharmaceutically acceptable salt thereof, can be used as a pharmaceutical ingredient having antagonistic activity against the EP4 receptor, for prevention and/or treatment of diseases caused by the activation of the EP4 receptor.本發明係提供用於預防及/或治療由於EP4受體活化而引起之疾病之藥劑，該藥劑係以對於EP4受體具有拮抗活性之化合物作為有效成分。通式(I)表示之化合物或其藥學上容許之鹽 (式中，所有符號表示與說明書記載之符號同意義)對預防及/或治療由於EP4受體活化而引起之疾病方面，可用於做為對於EP4受體具有拮抗活性之藥劑成分。
