Provided is a drug the active ingredient of which is a compound having antagonistic activity against EP 4 receptor in the prevention and/or treatment of disease attributed to activation of EP 4 receptor. The compound represented by general formula (I) (where all symbols in the formula are the same as the symbols defined in the specification) and a salt, N-oxide, and solvate of such compound, as well as prodrugs of the foregoing, are useful as a drug ingredient having antagonistic activity against EP 4 receptor in the prevention and/or treatment of disease attributed to activation of EP 4 receptor.
