3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein

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专利权人:

Institute of Organic Chemistry and Biochemistry ASCR; v.v.i.

发明人:

BIRKUS, Gabriel,PAV, Ondrej,JANDUSIK, Tomas,ROSENBERG, Ivan,NENCKA, Radim

申请号：

AU2018392213

公开号：

AU2018392213A1

申请日:

2018.12.19

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Provided herein are the 3'3' cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

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