INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR; V.V.I.
发明人:
BIRKUS, GABRIEL,PAV, ONDREJ,ROSENBERG, IVAN,SIMAK, ONDREJ
申请号：
CA3093886
公开号：
CA3093886A1
申请日:
2019.04.04
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present disclosure relates to 2'3'-cyclic dinucleotides modified with a 2'- or 3'-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein (IA) or a compound of Formula (1B) or pharmaceutically acceptable salt thereof wherein L1 is -O- or -K-C(R6R7)-； L2 is -K-C(R6R7)-；
