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Quinazolin-4 (3H) –ona antibacterial derivatives
专利权人:
Idorsia Pharmaceuticals Ltd
发明人:
GAUVIN, Jean-Christophe,SURIVET, Jean-Philippe,CHAPOUX, Gaëlle,MIRRE, Azely
申请号:
ES15722212
公开号:
ES2687040T3
申请日:
2015.05.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula I ** Formula ** in which R1 is H or halogen; R2 is the group M; R3 is H or halogen; M is one of the groups MA and MB represented below ** Formula ** in which A represents a bond or C≡C; R1A is H or halogen; R2A is H, (C1-C3) alkoxy or halogen; R3A is H, (C1-C3) alkoxy, hydroxyalkoxy (C2-C4), hydroxyalkyl (C1-C4), 1,2-dihydroxyethyl, dialkylamino (C1-C3), 1- hydroxymethyl-cycloprop-1-yl, 1- ((dimethylglynyl) oxy) methyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, morpholin-4-yl-alkyl (C1-C2) or morpholin-4-yl-alkoxy (C2-C3); and R1B is hydroxyalkyl (C1-C3), aminoalkyl (C1-C3), [dialkylamino (C1-C3)] - (C1-C3) alkyl, 1,2-dihydroxypropyl-3-yl, 1-amino-cycloprop-1 -yl, 1-hydroxymethyl-cycloprop-1-yl, 1 - ((phosphonooxy) methyl) cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, trans-2-aminomethyl-cycloprop-1-yl , 1-fluoro-2-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-1-methyl-cycloprop-1-yl, 2-fluoro-2-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl -2-methyl-cycloprop-1-yl, 1- (1,2-dihydroxyethyl) -cycloprop-1-yl, trans-2- (1,2-dihydroxyethyl) -cycloprop-1-yl, 1- (hydroxymethyl) cyclobut-1-yl, 3-hydroxyoxetan-3-yl, 3- (hydroxyalkyl (C1-C3)) oxetan-3-yl, 3-hydroxyetietan-3-yl, trans- (cis-3,4-dihydroxy) - cyclopent-1-yl, 3- (2-aminoacetamido) cyclopentyl, 3-hydroxymethylbicyclo [1.1.1] pentan-1-yl or 3-hydroxyoxetan-3-ylmethyl; or a salt of this compound.Un compuesto de fórmula I**Fórmula** en la que R1 es H o halógeno; R2 es el grupo M; R3 es H o halógeno; M es uno de los grupos MA y MB representados a continuación**Fórmula** en las que A representa un enlace o C≡C; R1A es H o halógeno; R2A es H, alcoxi (C1-C3) o halógeno; R3A es H, alcoxi (C1-C3), hidroxialcoxi (C2-C4), hidroxialquilo (C1-C4), 1,2-dihidroxietilo, dialquilamino (C1-C3), 1- hidroximetil-cicloprop-1-ilo, 1-((dimetilglicil)oxi)metil-cicloprop-1-ilo, 3-hidroxioxetan-3-ilo, morfolin-4-il- alquilo (C1-C2) o morfolin-4-ilalcoxi (C2-C3); y R1B es hidroxialquilo (C1-C3), aminoalq
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