Wearable diagnostic and treatment devices for performing point of care diagnostic tests for detecting, quantifying, analyzing, and treating at least one biological or environmental condition. Such testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like where, in the past, only qualitative or semi-quantitative results have typically been available. Likewise, such devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing devices may include automated data reporting and decision support. Further, such devices may include drug delivery or other treatment options.