РАТ Маттиас (US),НИДЗВЕЦКИ Александра (US),РУМИ Вахид М. (US)
申请号：
RU2013139439/15
公开号：
RU2013139439A
申请日:
2011.07.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method comprising identifying an oligopeptide sequence of a matrix metalloproteinase expressed in a particular disease； synthesizing an oligopeptide sequence of this metalloproteinase； generating a therapeutically effective amount of a therapeutic composition using the oligopeptide sequence of this metalloproteinase； preparing a pharmaceutical composition using a therapeutic composition to treat a mammal suffering from a particular disease accompanied by excessive ex a compression of the matrix metalloproteinase in which the oligopeptide sequence of the matrix metalloproteinase is at least one of the sequences of SEQ ID NO: 1-21 and combinations thereof. 2. The method of claim 1, wherein the oligopeptide sequence of the matrix metalloproteinase is at least one of the sequences of SEQ ID NO: 2-21, in particular one of the sequences of SEQ ID NO: 2-4.3. The method of claim 1, wherein the pharmaceutical composition is a vaccine. The method of claim 2, wherein the pharmaceutical composition is a vaccine. The method according to one of the preceding claims, wherein the particular disease is at least one of neoplastic diseases (especially cancer), inflammatory diseases, coronary heart disease and other coronary artery lesions, occlusive cardiovascular diseases, degenerative and infectious diseases. . The method according to any one of paragraphs. 1-4, in which the introduction of the pharmaceutical composition is carried out by at least one of the non-invasive methods of oral, local, enteral administration,1. Способ, включающийидентификацию олигопептидной последовательности матриксной металлопротеиназы, экспрессирующейся при конкретном заболевании；синтез олигопетидной последовательности этой металлопротеиназы；выработка терапевтически эффективного количества лечебной композиции с использованием олигопептидной последовательности этой металлопротеиназы；получение фармацевтической композиции с использованием лечебной композиции с целью лечения млекопитающего, страдающего
