БЕРРИ Лини (US),ФИЛЛИПС Гейл Льюис (US),СЛИВКОВСКИ Марк Кс. (US)
申请号：
RU2010142390/15
公开号：
RU2010142390A
申请日:
2009.03.10
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of treating a hyperproliferative disorder, comprising administering a therapeutic combination in the form of a combination composition, or alternately to a mammal, in which the therapeutic combination comprises a therapeutically effective amount of trastuzumab-MCC-DM1 and a therapeutically effective amount of a chemotherapeutic agent selected from an HER2 dimerization inhibitor antibody, an anti-VEGF antibody , 5-FU, carboplatin, lapatinib, ABT-869, docetaxel, GDC-0941 and GNE-390. ! 2. The method of claim 1, wherein the HER2 dimerization inhibitor antibody is Pertuzumab. ! 3. The method of claim 1, wherein the anti-VEGF antibody is bevacizumab. ! 4. The method according to claim 1, wherein the chemotherapeutic agent is 5-FU. ! 5. The method according to claim 1, in which the chemotherapeutic agent is carboplatin. ! 6. The method according to claim 1, in which the chemotherapeutic agent is lapatinib. ! 7. The method according to claim 1, in which the chemotherapeutic agent is ABT-869. ! 8. The method according to claim 1, in which the chemotherapeutic agent is docetaxel. ! 9. The method according to claim 1, in which the chemotherapeutic agent is GDC-0941. ! 10. The method according to claim 1, in which the chemotherapeutic agent is GNE-390. ! 11. The method according to claim 1, wherein a therapeutically effective amount of trastuzumab-MCC-DM1 and a therapeutically effective amount of a chemotherapeutic agent are administered as a combined composition. ! 12. The method according to claim 1, in which a therapeutically effective amount of trastuzumab-MCC-DM1 and a therapeutically effective amount of a chemotherapeutic agent are administered alternately. ! 13. The method according to item 12, in which the mammal is administered a chemotherapeutic agent and then subsequently1. Способ лечения гиперпролиферативного нарушения, включающий введение терапевтической комбинации в виде комбинированной композиции или поочередно млекопитающему, в котором терапевтическ
