РУГГ Кёртис Л. (US),СТОУН Хонгрэн Ф. (US),ВОГ Джекоб М. (US)
申请号：
RU2011125775/15
公开号：
RU2011125775A
申请日:
2009.12.28
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of administering botulinum toxin to achieve a therapeutic or cosmetic effect in an individual in need thereof, comprising: injecting an effective amount of a composition to an individual to achieve a therapeutic or cosmetic effect, the composition comprising: a positively charged carrier comprising a positively charged backbone with many attached to her groups of efficacy, a complex of botulinum toxin, a "reduced" complex of botulinum toxin or botulinum toxin； but a charged carrier is non-covalently bound to a botulinum toxin complex, a “reduced” botulinum toxin complex, or botulinum toxin. 2. The method according to claim 1, characterized in that the botulinum toxin complex, reduced botulinum toxin complex or botulinum toxin are obtained from serotypes A, B, C, D. E, F or G of C. botulinum. 3. The method according to claim 1, characterized in that the positively charged main chain is a polyamino acid. The method according to claim 3, characterized in that the polyamino acid is selected from the group consisting of polylysine, polyarginine, polyhistidine and polyornithine. The method according to claim 1, characterized in that the groups conferring efficacy are an amino acid sequence selected from the group consisting of (gly) - (arg), HIV-TAT or its fragments, the transduction domain of the Antennapedia protein or its fragment, ( gly) -RGRDDRRQRRR- (gly), (gly) -YGRKKRRQRRR- (gly) or (gly) -RKKRRQRRR- (gly) and SGRQIKIWFQNRRMKWKKC； where n1 is an integer from 0 to 20, n2 is independently an odd number from about 5 to about 25, more preferably from about 7 to about 17, most preferably from about 7 to about 17； and the indices p and q each not1. Способ введения ботулотоксина для достижения терапевтического или косметического эффекта у индивидуума, нуждающегося в этом, включающий:инъекцию эффективного количества композиции индивидууму для достижения терапевтического или косметического эффекта,при этом композиция содержит:положительно заряженный носитель, в
