AMERICAN HOME PRODUCTS CORPORATION;RESEARCH FOUNDATION FOR MEDICAL HYGIENE
发明人:
PETANESCA, SUZANA,GANDY, SAM,FRAIL, DONALD E.
申请号：
CA20002390161
公开号：
CA2390161(A1)
申请日:
2000.11.03
申请国别(地区):
加拿大
年份:
2001
代理人:
摘要：
The present invention relates to identification of agents that play a role i n regulating brain amyloid-.beta. (A.beta.) levels in vivo. The invention provides compounds and methods of using such compounds to treat amyloidogeni c conditions. It also provides a useful animal model for screening for and evaluating candidate amyloid inhibiting or therapeutic compounds. In particular, ovariectomy (ovx) and estrogen replacement were found to affect brain A.beta. levels in guinea pigs. Long-term ovx of guinea pigs resulted i n increased levels of total brain A.beta., as compared to intact animals, and the A.beta.42/A.beta.40 ratio was also elevated. Treatment of ovx guinea pig s with .beta.17-estradiol for ten days partially reversed the ovx-associated increase in brain A.beta. levels.
