The invention provides a method for obtaining a composition, the method comprising the steps of: (a) combining an amount of an active agent with a carrier to provide a diluted formulation； (b) taking an amount of diluted formulation and combining it with carrier to provide a more diluted formulation； (c) taking an amount of the more diluted formulation and combining it with carrier to provide a yet more diluted formulation, (d) repeatedly carrying out the step of taking the most diluted version of the formulation and combining an amount of said formulation with carrier, until a final formulation is obtained where the concentration of the active agent is less than 1 x 10‑10ppm； wherein the steps of (a) to (d), in which active agent is combined with carrier, are carried out over a period of time of an hour or more； and then (e) combining an amount of the final formulation with one or more skin composition ingredients, to provide a skin composition where the concentration of the active agent is less than 1 x 10-11ppm.本發明提供一種獲得一組成物之方法，該方法包括下列步驟：(a) 將一定量之一活性劑與一載體結合以提供一稀釋配方；(b) 取一定量之該稀釋配方並將其與該載體結合以提供一再稀釋配方；(c) 取一定量之該再稀釋配方並將其與該載體結合以提供一更稀釋配方；(d) 反覆地進行取得該配方之最稀釋版本並將一定量之該最稀釋版本配方與該載體結合之步驟直到獲得一最終配方，該最終配方中該活性劑濃度小於1 x 10‑10ppm；其中，該(a)至(d)之步驟中，活性劑與載體之結合係進行一小時以上之一段時間；且接著將一定量之該最終配方與一種或以上皮膚用組成物成分結合以提供一皮膚用用組成物，其中，該活性劑濃度小於1 x 10‑11ppm。其中，該(a)至(d)之步驟中，活性劑與載體之結合係進行一小時以上之一段時間；且接著(e) 將一定量之該最終配方與一種或以上皮膚用組成物成分結合以提供一皮膚用用組成物，其中，該活性劑濃度小於1 x 10 11ppm。
