The invention provides a method for obtaining a composition, the method comprising the steps of: (a) combining an amount of an active agent with a carrier to provide a diluted formulation； (b) taking an amount of diluted formulation and combining it with carrier to provide a more diluted formulation； (c) taking an amount of the more diluted formulation and combining it with carrier to provide a yet more diluted formulation, (d) repeatedly carrying out the step of taking the most diluted version of the formulation and combining an amount of said formulation with carrier, until a final formulation is obtained where the concentration of the active agent is less than 1×10−10 ppm； wherein the steps of (a) to (d), in which active agent is combined with carrier, are carried out over a period of time of an hour or more； and then (e) combining an amount of the final formulation with one or more skin composition ingredients, to provide a skin composition where the concentration of the active agent is less than 1×10−11 ppm.
