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COMPOSÉ HÉTÉROCYCLIQUE BICYCLIQUE
专利权人:
Astellas Pharma Inc.
发明人:
申请号:
EP12840990.1
公开号:
EP2772484B1
申请日:
2012.10.17
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
[Problem] To provide a compound useful as an active ingredient of a pharmaceutical composition for treating 11²-hydroxysteroid dehydrogenase type 1-related diseases such as dementia, schizophrenia, depression, pain (particularly, neuropathic pain or fibromyalgia), diabetes (particularly, type II diabetes mellitus), insulin resistance and the like. [Means for Solution] A bicyclic heterocyclic compound (the bicyclic heterocycle is formed when a cyclohexane ring is fused with a 5- to 6-membered monocyclic heterocycle that has only a nitrogen atom as a hetero atom) substituted with an acylamino group such as a (hetero)aroylamino group or the like or a pharmaceutically acceptable salt thereof was found to have an excellent selective inhibitory action against 11²-HSD1. Accordingly, the bicyclic heterocyclic compound of the present invention can be used for treating dementia, schizophrenia, depression, pain (particularly, neuropathic pain or fibromyalgia), diabetes (particularly, type II diabetes mellitus), insulin resistance, and the like.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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