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Bicyclic heterocyclic compound
专利权人:
Astellas Pharma Inc.
发明人:
Kawakami, Shimpei,Sakurai, Minoru,Kawano, Noriyuki,Suzuki, Takayuki,Shiraishi, Nobuyuki,Hamaguchi, Wataru,Sekioka, Ryuichi,Moritomo, Hiroyuki,Moritomo, Ayako
申请号:
AU2012327076
公开号:
AU2012327076B2
申请日:
2012.10.17
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
[Problem] To provide a compound useful as the active ingredient in a drug composition for treating diseases to which 11β-hydroxysteroid dehydrogenase type 1 contributes such as dementia, schizophrenia, depression, pain (particularly neuropathic pain and fibromyalgia), diabetes (particularly type 2 diabetes), and insulin resistance. [Solution] It was discovered that a bicyclic heterocyclic compound substituted with an acylamino group such as a (hetero)aroylamino group (the bicyclic heterocycle being formed by condensing a cyclohexane ring and a 5- or 6-membered monocyclic heterocycle having only a nitrogen atom as the heteroatom) or a pharmaceutically acceptable salt thereof has a superior selective inhibitory action with respect to 11β-HSD1. Thus, the bicyclic heterocyclic compound can be used in the treatment of dementia, schizophrenia, depression, pain (particularly neuropathic pain and fibromyalgia), diabetes (particularly type 2 diabetes), insulin resistance, and the like
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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