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BICYCLIC HETEROCYCLIC COMPOUND
专利权人:
ASTELLAS PHARMA INC.
发明人:
KAWAKAMI SHIMPEI,SAKURAI MINORU,KAWANO NORIYUKI,SUZUKI TAKAYUKI,SHIRAISHI NOBUYUKI,HAMAGUCHI WATARU,SEKIOKA RYUICHI,MORITOMO HIROYUKI,MORITOMO AYAKO
申请号:
IN2949CHN2014
公开号:
IN2949CHN2014A
申请日:
2014.04.17
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
[Problem] To provide a compound useful as the active ingredient in a drug composition for treating diseases to which 11ß hydroxysteroid dehydrogenase type 1 contributes such as dementia schizophrenia depression pain (particularly neuropathic pain and fibromyalgia) diabetes (particularly type 2 diabetes) and insulin resistance. [Solution] It was discovered that a bicyclic heterocyclic compound substituted with an acylamino group such as a (hetero)aroylamino group (the bicyclic heterocycle being formed by condensing a cyclohexane ring and a 5 or 6 membered monocyclic heterocycle having only a nitrogen atom as the heteroatom) or a pharmaceutically acceptable salt thereof has a superior selective inhibitory action with respect to 11ß HSD1. Thus the bicyclic heterocyclic compound can be used in the treatment of dementia schizophrenia depression pain (particularly neuropathic pain and fibromyalgia) diabetes (particularly type 2 diabetes) insulin resistance and the like
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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