Agency for Science, Technology and Research;National University of Singapore
发明人:
申请号：
EP16807931.7
公开号：
EP3307874A4
申请日:
2016.06.10
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
This application describes liver stem cells (LSC), and differentiated hepatocytes, cholangiocytes, and 3D cellular structures derived therefrom. Methods for producing LSC and mature, differentiated hepatocytes and cholangiocytes in culture are provided. Also provided are cell culture systems and cell culture media for producing a homogenous population of liver stem cells that remain in an undifferentiated state over multiple passages in culture. The LSC and methods are useful for producing homogenous populations of hepatocytes and cholangiocytes for downstream applications. The LSC can be transplanted into subjects to treat liver diseases.
