KADEREIT, DIETER,SCHÄFER, MATTHIAS,HACHTEL, STEPHANIE,HUEBSCHLE, THOMAS,HISS, KATRIN
申请号：
ES12732677
公开号：
ES2544620T3
申请日:
2012.07.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of the formula I in one of its arbitrary stereoisomeric forms or a mixture of stereoisomeric forms in an arbitrary relationship or a physiologically acceptable salt thereof or a physiologically acceptable solvate of such a compound or of such a salt ** Formula ** where A is chosen as the link, -CH2-, NH, O and S； X is chosen from (C1-C6) alkane, (C2-C6) alkene, di (C2-C6) alkyne, cycloalkane (C3-C7) -diyl, (C1-C6) alkane and cycloalkane (C3-C7) -diyloxy, all of which are eventually substituted with one or more identical or different substituents that are chosen from fluorine and hydroxy, the oxygen atom being from the (C1-C6) -diyloxy and cycloalkane (C3) alkane groups -C7) -diyloxy attached to the group Y； And it is chosen from phenylene and from a bivalent radical of an aromatic monocyclic heterocycle, from 5 members to 6 members, containing 1, 2 or 3 heteroatoms of the same or different ring which are chosen from N, O and S, wherein one of the nitrogen atoms of the ring may carry a hydrogen atom or an R4 substituent, and wherein the phenylene and the bivalent radical of an aromatic heterocycle are optionally substituted at one or more carbon atoms of the ring by the same or different R5 substituents； R1 is chosen from hydrogen, (C1-C4) alkyl and cycloalkyl (C3-C7) -CzH2z-, wherein z is chosen from 0, 1 and 2； R2 is chosen from (C1-C6) alkyl, cycloalkyl (C3-C5) -CxH2x-, Het1-CnH2n-, wherein x and n are chosen from 0, 1 and 2； R3 is chosen from (C1-C6) alkyl, wherein the alkyl radical is optionally substituted with one or more fluorine atoms, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C7) -CuH2- cycloalkyl and Het2-CvH2v-, where u and v are chosen from 1 and 2, or R3 represents a radical of a monocyclic or bicyclic ring, saturated or unsaturated, from 3 members to 10 members, containing 0, 1, 2, 3 or 4 same or different ring heteroatoms that are chosen from N, O and S, wherein one or two of the ring's nitrogen atoms can carry a hydrogen atom or a (C1-C4) alkyl
