Sphingosine 1- phos phate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups

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专利权人:

University of Virginia Patent Foundation

发明人:

MacDonald, Timothy L.,Lynch, Kevin R.

申请号：

AU2006214314

公开号：

AU2006214314B2

申请日:

2006.02.14

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, -substituted phosphonates, and phosphothionates.

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