Sphingosine 1- phos phate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups

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专利权人:

University of Virginia Patent Foundation

发明人:

Not Given

申请号：

AU2012202703

公开号：

AU2012202703A1

申请日:

2012.05.08

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2012202703A120120531.pdf#####Abstract of the Disclosure The present invention provides sphingosine- 1-phosphate analogs that are potent, and selective agonists at one or more Si P receptors, specifically the SIP, receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds with hydrolysisresistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.

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