COMBINAÇÃO DUM INIBIDOR DE REDUTASE HMG-COA E DUM INIBIDOR DE SINTASE DE FARNESIL-PIROFOSFATASE PARA TRATAR DOENÇAS RELACIONADAS COM A ACUMULAÇÃO E/OU A PERSISTÊNCIA DE PROTEINAS PRENILADAS
UNIVERSITÉ D'AIX-MARSEILLE;ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES (AFM);ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE;UNIVERSIDAD DE OVIEDO
发明人:
NICOLAS LEVY,PIERRE CAU,CARLOS LOPEZ-OTIN
申请号：
PT15160222
公开号：
PT2921172T
申请日:
2007.07.05
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological aging.
