Dennis Leung,Todd D. Nelson,Timothy A. Rhodes,Elizabeth Kwong
申请号：
US14354187
公开号：
US09381518B2
申请日:
2012.10.26
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Described herein is a process for preparing nano-suspensions, wherein the process comprises: providing an admixture of at least one active pharmaceutical compound, an aqueous dispersion medium, and milling media and applying thereto acoustic energy having a frequency of from about 10 hertz to 1000 hertz and which supplies a linear acceleration of from about 10 Gs to about 100 Gs (where “G” is the force of gravity) for a period sufficient to supply a nano-suspension having a D50 of less than about 1 micron, preferably less than about 500 nm. Described also are nano-suspensions having novel properties prepared via the inventive process.
