NOUVEAUX COMPOSES DE LIAISON DE RADIOMETAUX POUR LE DIAGNOSTIC OU LE TRAITEMENT DU CANCER EXPRIMANT UN ANTIGENE MEMBRANAIRE SPECIFIQUE DE LA PROSTATE

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专利权人:

THE UNIVERSITY OF BRITISH COLUMBIA;PROVINCIAL HEALTH SERVICES AUTHORITY

发明人:

LIN, KUO-SHYAN,BENARD, FRANCOIS,KUO, HSIOU-TING,ZHANG, ZHENGXING

申请号：

CA3079906

公开号：

CA3079906A1

申请日:

2018.10.22

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

This application relates to compounds of Formula (I-a) or Formula (I-b), or is salts or solvates thereof. R1 is -(CH2)5CH3 or comprises 2-4 fused benzene rings. R2 is I, Br, F, Cl, H, OH, OCH3, NH2, NO2 or CH3. R3 is a peptide-bonded glycine, aspartate or glutamate or is glutamate peptide bonded through Cdelta. L is CH2NH, (CH2)2NH, (CH2)3NH, or (CH2)4NH. R4 is a radiometal chelator optionally bound by a radiometal. Variable 'n' is 1-3. The compounds may be useful for imaging prostate specific membrane antigen (PSMA)-expressing tissues or for treating PSMA-expressing diseases (e.g. cancer).

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