(57)< Abstract > Being remedy manner of the neurohumor malfunction symptom which is pulled up by the denaturation of heart function in order to preventing the development of heart failure or the manner which augments the calcium sensitivity of the contractile Characteristic protein of the myocardium, in Mammalia where that kind of remedy is necessary (R) N - [the 4 (1,4,5,6 tetrahydro 6 oxo 3 piridajiniru) phenyl] the manner which consists of the fact that the effective tonnage it prescribes acetamide.心不全の進展を防止するための心機能の変性によって引き起こされる神経液失調症の治療方法または心筋の収縮性タンパク質のカルシウム感受性を増加させる方法であって、そのような治療が必要な哺乳類に(R)-N‐[4-(1,4,5,6-テトラヒドロ-6-オキソ-3-ピリダジニル)フェニル]アセトアミドを有効量投与することからなる方法。