ALMENA-PEREA, JUAN JOSE,BRINK, MONICA,GEISS, GERHARD,KADYROV, RENAT,MEYER, THORSTEN
申请号：
CA2675651
公开号：
CA2675651C
申请日:
2008.01.31
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,l-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin- 2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterolor a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.
