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process for the preparation of aryl ethanol amine derivatives having anti-obesity and anti-diabetic properties
专利权人:
GLAXO GROUP LIMITED
发明人:
ALAN MILLAR,RONNIE MAXWELL LAWRENCE
申请号:
BR0016187
公开号:
BRPI0016187B1
申请日:
2000.12.08
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
"Process for the preparation of aryl ethanol amine derivatives having anti - obesity and anti diabetic properties". a process for preparing a compound of formula (ia) or a pharmaceutically acceptable salt thereof; where R2 is an aryl, pyridyl, thiazolyl, phenoxy methyl, or pyrimidyl group, optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, C1-6 alkoxy, C1-6 alkyl -, hydroxy methyl, trifluoromethyl, -nr4-6-6-6, and -nhso-2-6-6-6, wherein each R2-6 is independently hydrogen, or C1-4-alkyl; R2 is hydrogen or C1-6 alkyl; R ^ 3 ^ is co-2 ~ R ^ 7 ^ where r ^ 7 ^ is hydrogen or C 1-6 alkyl; R4 and R5 are independently hydrogen, C1-6 alkyl, or -co2-6 C1-6 alkyl; and y is n or ch comprising the step of preparing a diamide of formula (ii) or a pharmaceutically acceptable salt thereof; where R2 is an aryl, pyridyl, thiazolyl, phenoxy methyl, or pyrimidyl group, optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, C1-6 alkoxy, C1-6 alkyl -, hydroxy methyl, trifluoromethyl, -nr4-6-6-6, and -nhso-2-6-6-6, wherein each R2-6 is independently hydrogen, or C1-4-4 alkyl; R2 is hydrogen or C1-6 alkyl; r ^ 3 ^ is co-2 ~ r ^ 7 ^ where r ^ 7 ^ is C 1-6 alkyl; R 4 and R 5 are independently hydrogen, C 1-6 alkyl, C 2 -C 6 alkyl; and y is n or ch."processo para a preparação de derivados de aril etanol amina tendo propriedades anti - obesidade e anti diabéticas". processo para a preparação de um composto de fórmula (ia) ou um seu sal farmaceuticamente aceitável; onde r^ 1^ é um grupo arila, piridila, tiazolila, fenoxi metila, ou pirimidila, opcionalmente substituído com um ou mais substituintes selecionados do grupo consistindo em halogênio, hidroxi, alcoxi c~ 1-6~, alquila c~ 1-6~, hidroxi metila, triflúor metila, -nr^ 6^r^ 6^, e -nhso~ 2~r^ 6^, onde cada r^ 6^ é independentemente hidrogênio, ou alquila c~ 1-4~; r^ 2^ é hidrogênio ou alquila c~ 1-6~; r^ 3^ é co~ 2~r^ 7^ onde r^ 7
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