BIRSNER, ULRICH,JUMAA, HASSAN,KLAPPROTH, HOLGER,KESSEMEIER, MARC A.
申请号：
CA3070848
公开号：
CA3070848A1
申请日:
2018.07.05
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to the field of the preparation, identification and selection of biological binding molecules such as antibodies or fragments thereof, and also the use thereof in the context of therapy and prophylaxis of cancers, such as malignant B-cell neoplasia in particular. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, wherein the autonomously active or autonomously activated B-cell receptors are characterized by the presence of structural domains to which the binding molecule selectively binds and which cause the autonomously active or autonomously activated state of the B-cell receptors.
