The Jackson Laboratory;University of Massachusetts
发明人:
Leonard D. Shultz,James G. Keck,Dale L. Greiner,Michael A. Brehm
申请号：
US16465006
公开号：
US20190320633A1
申请日:
2017.11.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A genetically-modified, immunodeficient mouse is provided along with methods of use, wherein the mouse includes (a) a nucleotide sequence encoding human stem cell factor (hSCF)； (b) a nucleotide sequence encoding human granulocyte-macrophage colony-stimulating factor (hGM-CSF)； (c) a nucleotide sequence encoding human interleukin-3 (hIL-3)； and (d) a nucleotide sequence encoding human colony-stimulating factor 1 (hCSF1), wherein each of the nucleotide sequences is operably linked to a promoter, and wherein the genetically-modified, immunodeficient mouse expresses hSCF, hGM-CSF, hIL-3, and hCSF1, wherein the genetically-modified, immunodeficient mouse allows engraftment of human hematopoietic stem cells along with engraftment of human-patient derived tumor xenografts and/or human tumor cell lines to enable in vivo investigation of the interactions between the human immune system and human cancer.
