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ERK inhibitors and methods of use
- 专利权人:
- Inc.;Kura Oncology
- 发明人:
- LI, Liansheng,WU, Tao,FENG, Jun,REN, Pingda,LIU, Yi
- 申请号：
- ES14850964
- 公开号：
- ES2664794T3
- 申请日:
- 2014.10.03
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- Compound of Formula II-E: ** / See formula) ** or a pharmaceutically acceptable salt thereof； wherein: R1 is ** (See formula) ** or each of which is unsubstituted or substituted with one or more independent R10 or R11 substituents； R21 is hydrogen, halogen, -OH, -CF3, -OCF3, -OR31, -NR31R32, -C (O) R31, -CO2R31, -C (>； = O) NR31, -NO2, -CN, - S (O ) 0-2R31, -SO2NR31R32, -NR31C (>； = O) R32, -NR31C (>； = O) OR32, -NR31C (>； = O) NR32R33, -NR31S (O) 0-2R32, -C (>； = S ) OR31, - C (>； = O) SR31, -NR31C (>； = NR32) NR32R33, -NR31C (>； = NR32) OR33, -NR31C (>； = NR32) SR33, -OC (>； = O) OR33, -OC (>； = O) NR31R32, - OC (>； = O) SR31, -SC (>； = O) SR31, -P (O) OR31OR32, -SC (>； = O) NR31R32, -L-C1-10 alkyl, - L-C2-10 alkenyl, -L-C2-10 alkynyl, -L-C1-10 heteroalkyl, -L-C3-10 aryl, -L-C1-10 heteroaryl, -L-C3-10 cycloalkyl, -L- C1-10 heterocyclyl, -L-C1-10 alkyl-C3-10 aryl, -L-C1-10 alkyl-C1-10 heteroaryl, -L-C1-10 alkyl-C3-10 cycloalkyl, -L-C1-alkyl 10-10-heterocyclyl C1-10, -L-C2-10 alkenyl-C3-10 aryl, -L-C2-10 alkenyl-C1-10 heteroaryl, -L-C2-10 alkenyl-C3-10 cycloalkyl, -L-alkenyl C2-10-C1-10 heterocyclyl, -L-C2-10 alkynyl-C3-10 aryl, -L-C2-10 alkynyl-C1-10 heteroaryl, -L-C2-10 alkynyl-C3-10 cycloalkyl, -L -C2-10 alkynyl-C1-10 heterocyclyl, -L-C1-10 alkoxy-C3-10 aryl, -L-C 1-10 alkoxy-C 1-10 heteroaryl, -L-C 1-10 alkoxy-C 3-10 cycloalkyl, -L-C 1-10 alkoxy-C 1-10 heterocyclyl, -L-hetero-C 1-10 alkyl-C 3- aryl- 10, -L-C 1-10 heteroalkyl-C 1-10 heteroaryl, -L-C 1-10 heteroalkyl-C 3-10 cycloalkyl, -L-C 1-10 heteroalkyl-C 1-10 heterocyclyl, -L-C 3-10 alkyl-aryl C1-10, -L-C3-10 aryl-C2-10 alkenyl, -L- C3-10 aryl-C2-10 alkynyl, -L-C3-10 aryl-C1-10 heteroaryl, -L-C3-10 aryl -C3-10 cycloalkyl, -L-C3-10 aryl-C1-10 heterocyclyl, -L- C1-10 heteroaryl-C1-10 alkyl, -L-C1-10 heteroaryl-C2-10 alkenyl, -L-C1-heteroaryl -10-C2-10 alkynyl, -L-C 1-10 heteroaryl-C3-10 aryl, - L-C 1-10 heteroaryl-C 3-10 cycloalkyl, -L-C 1-10 heteroaryl-C 1-10 heterocyclyl, -L- C3-10
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
