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PROCEDE DE PREPARATION D'UNE DISPERSION SOLIDE AMORPHE DANS LE DOMAINE SUBMICRONIQUE PAR COPRECIPITATION
专利权人:
HOVIONE INTERNATIONAL LTD
发明人:
TEMTEM, MARCIO,PEREIRA, RUBEN,VICENTE, JOAO,GASPER, FILIPE,DUARTE, IRIS
申请号:
CA2956732
公开号:
CA2956732A1
申请日:
2015.07.31
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present invention discloses a method for producing amorphous solid dispersions in a nanoparticulate form, through solvent controlled co-precipitation, using microfluidization/microreaction technology to promote high energy mixing/interaction at a micro and/or molecular level between the streams involved in the process. Feed streams, solvent and anti-solvent, are fed to an intensifier pump at individually controlled rates and forced to interact to micro-and/or nano-scale within a microreactor. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compositions containing the same.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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