A hybrid tissue engineered heart valve leaflet including a polyurethane core, such as a polycarbonate-based thermoplastic polyurethane like carbothane. The polyurethane core is enclosed within one or more layer of a patients cells and collagen. Also disclosed are hybrid tissue engineered heart valves, including a frame and at least two leaflets attached thereto in a configuration of a heart valve, wherein the leaflets are hybrid tissue engineered heart valve leaflets, and methods of making a hybrid tissue engineered heart valve for deployment in a patient.
