KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
LEE, Myung Kyu,이명규,MOKHTARIEH, Amir Abbas,목타리에아미르 아바스,CHUNG, Bong Hyun,정봉현,CHEONG, Sin Young,정신영,CHOI, Jong Min,최종민
申请号：
KRKR2013/004352
公开号：
WO2013/172669A1
申请日:
2013.05.16
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The present invention relates to: a method for manufacturing a nano-liposome containing a nucleic acid without an extrusion process, comprising the step of mixing a lipid solution in which a lipid is dissolved and an aqueous solution in which a nucleic acid is dissolved into a mixed solvent containing diethyl ether and ethanol and a kit for manufacturing a nano-liposome comprising the mixed solvent and the lipid mixture.La présente invention concerne : un procédé de fabrication dun nanoliposome contenant un acide nucléique sans processus dextrusion, ledit procédé comportant létape de mélange dune solution lipidique dans laquelle un lipide est dissous et dune solution aqueuse dans laquelle un acide nucléique est dissous dans un solvant mixte contenant du diéthyl éther et de léthanol un nécessaire pour la fabrication dun nanoliposome comportant le solvant mixte et le mélange lipidique.본 발명은 압출공정 없이 디에틸에테르(diethyl ether) 및 에탄올(ethanol) 함유 혼합 용매에 지질이 용해된 지질 용액과, 핵산이 용해된 수용액을 섞는 단계를 포함하는, 핵산 함유 나노 리포솜의 제조방법 및 혼합 용매 및 지질 혼합물을 구비한 나노 리포솜 제조용 키트에 관한 것이다.
