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Piperazinyl methyl phenyl cyclohexane compound
专利权人:
Limited;Daiichi Sankyo Company
发明人:
Narihiro Toda,Rieko Takano,Takeshi Shida,Takahiro Katagiri,Mitsuhiro Iwamoto,Shinji Ashida,Mami Yamazaki
申请号:
US13850981
公开号:
US08710060B2
申请日:
2013.03.26
申请国别(地区):
US
年份:
2014
代理人:
摘要:
To find a therapeutic and/or prophylactic agent for gastrointestinal disorders and so on, the agent having excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4- to 10-membered heterocyclic group, an optionally substituted C6-C10 aryl group, or an optionally substituted C3-C10 cycloalkyl group; R1 represents a hydrogen atom or a C1-C3 alkyl group; R2 represents a hydrogen atom or a C1-C3 alkyl group; R3 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C3 alkoxy C1-C3 alkyl group, or a C1-C3 hydroxyalkyl group; R4 represents a hydrogen atom, a C1-C6 alkyl group, or a halogen atom; n represents an integer of 1 to 4; and X represents methylene, —O—, —NH—, —N(C1-C3 alkyl)-, —C(═O)—, —S—, —S(O)—, —S(O2)—, or a single bond.
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