LAWRENCE MICHAEL COLIN AUSTRALIA,SMITH BRIAN JOHN AUSTRALIA,MENTING JOHN GERBRANDT TASMAN AUSTRALIA,WARD COLIN WESLEY AUSTRALIA
申请号：
IN8193/DELNP/2011
公开号：
IN2011DN08193A
申请日:
2011.10.21
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-IR). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR a-chain, as well as the corresponding region of IGF-IR, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-IR.
