Andrew J. MURPHY,Viktoria GUSAROVA,Mark W. SLEEMAN
申请号：
MX2015017575
公开号：
MX361859B
申请日:
2012.06.14
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hANGPTL3) is provided. The human anti-hANGPTL3 antibodies are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL3 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases； acute pancreatitis； nonalcoholic steatohepatitis (NASH)； diabetes； obesity； and the like.La presente invención se refiere a una molécula de ácido nucleico aislada que codifica un anticuerpo o fragmento de fijación antígeno del mismo, en donde el anticuerpo o fragmento de fijación de antígeno comprende un par HCVR/LCR de SEQ ID Nos: 66/74. Un método para producir el anticuerpo, una composición farmacéutica que contiene el ácido nucleico y usos médicos.
