W. MARK SLEEMAN,VIKTORIA GUSAROVA,JEE H. KIM,GANG CHEN
申请号：
MX2012007460
公开号：
MX337082B
申请日:
2010.12.23
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
A fully human antibody or antigen -binding fragment of a human antibody that specifically binds and inhibits human angiopoietin - like protein 4 (hANGPTL4) is provided. The human anti- hANGPTL4 antibodies are useful in treating diseases or disorders associated with ANGPTL4, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti -hANGPTL4 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases acute pancreatitis nonalcoholic steatohepatitis (NASH) diabetes obesity.La presente invención se refiere a un anticuerpo humano aislado o fragmento de unión a antígeno del mismo, que se une específicamente a proteína 4 de tipo angiopoyetina humana (hANGPTL4), que comprende una región 1 determinante de complementariedad de cadena pesada (HCDR1) /HCDR2/HCDR3 que comprende una combinación de secuencia de amino ácido de SEQ ID NO.: 28/30/32, y una región 1 determinante de complementariedad de cadena ligera (LCDR1)/LCDR2/LCDR3 que comprende una combinación de secuencia de amino ácido de SEC ID NO.: 36/38/40.
