SLEEMAN, MARK W.,GUSAROVA, VIKTORIA,MURPHY, ANDREW J.
申请号：
CA2838867
公开号：
CA2838867A1
申请日:
2012.06.14
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hANGPTL3) is provided. The human anti-hANGPTL3 antibodies are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL3 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases； acute pancreatitis； nonalcoholic steatohepatitis (NASH)； diabetes； obesity； and the like.
